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Updated: Sep 23, 2026
Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
A validated spectrofluorometric method for the determination of celecoxib in capsules
Patricia Damiani1, Mariela Bearzotti, Miguel A Cabezón
1Departamento de Química Analítica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. pdamiani@infovia.com.ar
Abstract:
A rapid, selective, sensitive and simple fluorescence method was developed for the direct determination of celecoxib in capsules. The capsules were emptied, pulverized and dissolved in either ethanol or acetonitrile, sonicated and filtered. Direct fluorescence emission was measured at 355+/-5 nm (exciting at 272 nm). The method was fully validated and the recoveries were excellent, even in presence of excipients.
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