Related Experiment Videos
Quantitative analysis of cortical pyramidal neurons after corpus callosotomy
Bob Jacobs1, Johanna Creswell, Jonathan P Britt
1Laboratory of Quantitative Neuromorphology, Department of Psychology, Colorado College, Colorado Springs, CO 80903, USA. bjacobs@coloradocollege.edu
Annals of Neurology
|July 3, 2003
Abstract:
This study quantitatively explored the dendritic/spine extent of supragranular pyramidal neurons across several cortical areas in two adult male subjects who had undergone a callosotomy several decades before death. In all cortical areas, there were numerous atypical, supragranular pyramidal neurons with elongated "tap root" basilar dendrites. These atypical cells could be associated with an underlying epileptic condition and/or could represent a compensatory mechanism in response to deafferentation after callosotomy.