Present angiogenesis research and its possible future implementation in wound care

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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

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L Cox1

  • 1South Warwickshire General Hospitals NHS Trust, Warwickshire, UK. lisacox@lisa58.freeserve.co.uk

Journal of Wound Care
|July 4, 2003
PubMed

Abstract:

The process of new blood vessel formation is essential for wound healing. Nurses should be aware of the latest scientific findings on angiogenesis which will enhance their understanding of how it may affect clinical practice.

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Mechanism of Angiogenesis01:10

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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