Related Experiment Video
Updated: Jul 21, 2026

Programmed Electrical Stimulation in Mice
Published on: May 26, 2010
[Cardiac stimulation in the infant and young child]
A Codreanu1, F Marçon, G Bosser
1Département des maladies cardiovasculaires du CHU de Nancy.
Insights
Comparing cardiac stimulation methods in infants, this study found both epicardial and endocavity routes to be comparable. Endocavity stimulation is recommended initially for infants due to technical reasons, with epicardial pacing preferred for dual-chamber needs.
Area of Science:
- Pediatric Cardiology
- Biomedical Engineering
- Medical Device Technology
Context:
- Infantile cardiac stimulation presents unique challenges.
- Evaluating long-term outcomes of epicardial versus endocavity pacing in young children is crucial.
- Retrospective analysis of 37 infants (<3.5 years) with cardiac pacemakers.
Purpose:
- To compare the efficacy and long-term outcomes of endocavity and epicardial cardiac stimulation routes in infants.
- To identify the optimal initial pacing strategy for pediatric patients.
- To assess the evolution and challenges associated with cardiac pacing in a pediatric cohort.
Summary:
- No significant difference in functional duration was found between epicardial and endocavity pacing.
- 14/19 epicardial cases transitioned to endocavity, while no endocavity cases switched to epicardial.
- Endocavity pacing is suggested initially for infants due to technical factors, with epicardial pacing suitable for dual-chamber requirements.
Impact:
- Provides evidence to guide the selection of initial cardiac pacing strategies in infants.
- Highlights the feasibility of endocavity pacing and the evolving role of epicardial pacing with improved electrodes.
- Informs clinical practice regarding the management and long-term care of pediatric patients requiring cardiac stimulation.
Abstract:
This study evaluates the problems and the evolution of cardiac stimulation in infants (aged < 3.5 years) by comparing the endocavity and epicardial routes in a retrospective series of 37 patients. Thirty seven patients aged 1.2 +/- 0.9 years treated with epicardial (n = 19) or endocavity (n = 18) stimulation were followed for 10.9 +/- 6.4 years (0.75-24). The 2 patient groups did not differ in age or weight. Four patients were lost to follow up, and 1 died. The functional duration of the first stimulator was not significantly different if the initial approach was epicardial or endocavity. The endocavity probes were introduced by venous denudation in 15 cases and by subclavian puncture in 3 cases. Fourteen of the 19 children fitted by the epicardial route went on to endocavity stimulation, of which 10 were at the first replacement. None of the 18 patients fitted by the endocavity route went on to epicardial stimulation. Out of 11 endocavity probe replacements and 9 atrialisations, the homolateral venous approach was always possible except in 2 cases. In conclusion, the results for the epicardial and endocavity routes are comparable. For technical reasons (calibre of the veins, size of the stimulator) it would appear reasonable if the endocavity route was used, making do initially with a mono chamber stimulation. The advances in the epicardial electrodes abolishes the major handicap (threshold elevation) of this approach which can be advocated when double chamber stimulation seems preferable.
Related Concept Videos
Electrophysiology of Normal Cardiac Rhythm
Mechanism of Cardiac Arrhythmias
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Cardiopulmonary Resuscitation III: AED Use

