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Convenient preparation and use of a new analytical construct for the analysis and development of solid-phase
Stephen P Andrews1, Mark Ladlow
1GlaxoSmithKline Cambridge Technology Center, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK.
The Journal of Organic Chemistry
|July 4, 2003
Abstract:
An expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin 14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions leading to the preparation of a small compound array 24(1-3,1-3). The optimized conditions are shown to work equally well on both the construct resin 14 and the corresponding base resin 15.