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Updated: Jul 27, 2026
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
[Study on the origin and differentiation of gastrointestinal stromal tumors]
Ying-yong Hou1, Xiong-zeng Zhu, Jian Wang
1Department of Pathology, Cancer Hospital, Medical College of Fudan University, Shanghai 200032, China.
Objective:
To explore the origin and differentiation of gastrointestinal stromal tumors (GISTs).
Methods:
Immunohistochemistry staining and electron microscopy were adopted.
Results:
In 212 cases of primary GISTs, the positive rates of CD117, CD34, alpha-SMA, MSA, desmin, S-100, PGP9.5 were 96.7%, 77.3%, 19.3%, 15.6%, 1.9%, 16.3%, and 12.3% respectively. Among them, GISTs showed a diffuse and strong positivity for CD117. Electron microscopy of tumor cells demonstrated numerous mitochondria, prominent perinuclear Golgi complex, smooth and rough endoplasmical reticulum and intermediate filaments. Irregular caveolae, dense plaque, incontinuous basal lamina were observed occasionally. Cytoplasmic processes were often observed accompanying with local adhesion present between the processes or between the processes and the cell membrane.
Conclusions:
Data from both immunophenotype and electron microscopy suggest that GIST might originate from the mesenchymal cells, differentiating to be ICC afterwards, and possessing myoid characteristics in various extent.
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