Novel antibody switching defects in human patients

Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center.

bioRxiv : the preprint server for biology·2026

Non-genotoxic transplantation and in vivo selection through epitope editing.

Nature·2026

Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model.

PLoS pathogens·2026

Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors.

Nature communications·2026

Long-term stability of posttranscriptional genetic silencing of BCL11A using a shmiR vector in Sickle Cell Disease.

Blood·2026

Linear RAG scanning mediates editing of Igκ variable region repertoires.

Nature·2026

Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Inhibiting STAT1 Signaling and MHC Class I Expression.

The Journal of clinical investigation·2026

Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation.

The Journal of clinical investigation·2026

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury.

The Journal of clinical investigation·2026

Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche in MASLD.

The Journal of clinical investigation·2026

METTL1-mediated m7G modification of valine tRNAs drives metabolic adaptation in pancreatic ductal adenocarcinoma.

The Journal of clinical investigation·2026

Targeting the E3 ubiquitin ligase RNF10 ameliorates metabolic dysfunction-associated steatohepatitis in mice.

The Journal of clinical investigation·2026

The why, what, who and when of B cell depletion in systemic lupus erythematosus: Biological rationale, patient stratification and evolving therapeutic modalities.

Rheumatology (Oxford, England)·2026

Immune checkpoint inhibitor-associated severe hyponatremia: evidence mapping of SIADH-like phenotypes and endocrine immune-related adverse events.

Endocrine connections·2026

Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: Clinical Presentation and Outcomes in Three Patients.

Journal of immunotherapy (Hagerstown, Md. : 1997)·2026

Giant cell arteritis during risankizumab therapy: a possible paradoxical reaction to IL-23 inhibition.

Immunological medicine·2026

Small Intestinal Extranodal Marginal Zone Lymphoma Mimicking Crohn's Disease.

ACG case reports journal·2026

A Pancreas Out of Place: Acute Interstitial Pancreatitis Caused by Pancreatic Herniation in a Type IV Paraesophageal Hernia.

ACG case reports journal·2026

Related Experiment Videos

Novel antibody switching defects in human patients

Related Concept Videos

Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center.

Non-genotoxic transplantation and in vivo selection through epitope editing.

Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model.

Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors.

Long-term stability of posttranscriptional genetic silencing of BCL11A using a shmiR vector in Sickle Cell Disease.

Linear RAG scanning mediates editing of Igκ variable region repertoires.

Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Inhibiting STAT1 Signaling and MHC Class I Expression.

Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation.

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury.

Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche in MASLD.

METTL1-mediated m7G modification of valine tRNAs drives metabolic adaptation in pancreatic ductal adenocarcinoma.

Targeting the E3 ubiquitin ligase RNF10 ameliorates metabolic dysfunction-associated steatohepatitis in mice.

The why, what, who and when of B cell depletion in systemic lupus erythematosus: Biological rationale, patient stratification and evolving therapeutic modalities.

Immune checkpoint inhibitor-associated severe hyponatremia: evidence mapping of SIADH-like phenotypes and endocrine immune-related adverse events.

Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: Clinical Presentation and Outcomes in Three Patients.

Giant cell arteritis during risankizumab therapy: a possible paradoxical reaction to IL-23 inhibition.

Small Intestinal Extranodal Marginal Zone Lymphoma Mimicking Crohn's Disease.

A Pancreas Out of Place: Acute Interstitial Pancreatitis Caused by Pancreatic Herniation in a Type IV Paraesophageal Hernia.

Related Experiment Videos

Novel antibody switching defects in human patients

Related Concept Videos

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