Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis of the migraine attack.

Egilius L H Spierings1

  • 1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

The Clinical Journal of Pain
|July 4, 2003
PubMed
Summary

Migraine headache involves arterial vasodilation and neurogenic inflammation. The brain stem may be the central driver of migraine attacks, influencing both aura and headache phases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Celecoxib Oral Solution and the Benefits of Self-Microemulsifying Drug Delivery Systems (SMEDDS) Technology: A Narrative Review.

Pain and therapy·2023
Same author

Cardiovascular outcomes in adults with migraine treated with eptinezumab for migraine prevention: pooled data from four randomized, double-blind, placebo-controlled studies.

The journal of headache and pain·2021
Same author

Improvements in quality of life and work productivity with up to 6 months of fremanezumab treatment in patients with episodic and chronic migraine and documented inadequate response to 2 to 4 classes of migraine-preventive medications in the phase 3b FOCUS study.

Headache·2021
Same author

Correction to: Safety and tolerability of eptinezumab in patients with migraine: a pooled analysis of 5 clinical trials.

The journal of headache and pain·2021
Same author

Efficacy and safety of fremanezumab in patients with migraine and inadequate response to prior preventive treatment: subgroup analyses by country of a randomized, placebo-controlled trial.

The journal of headache and pain·2021
Same author

Safety and tolerability of eptinezumab in patients with migraine: a pooled analysis of 5 clinical trials.

The journal of headache and pain·2021

Area of Science:

  • Neuroscience
  • Pathophysiology

Background:

  • Migraine pathogenesis involves extracranial arterial vasodilation, neurogenic inflammation, and reduced central pain inhibition.
  • Migraine aura is associated with cortical spreading depression, characterized by neuronal excitation followed by depression.

Purpose of the Study:

  • To present a conceptual model of migraine attack pathogenesis.
  • To explore the parallel relationship between migraine aura and headache mechanisms.

Main Methods:

  • Conceptual analysis of existing clinical and experimental evidence.
  • Integration of mechanisms underlying migraine aura and headache.

Main Results:

  • The mechanisms of migraine aura and headache may operate in parallel, not sequentially.
  • This parallel process is potentially influenced by migraine trigger factors.

Conclusions:

  • The brain stem is proposed as the central location for the process driving migraine pathogenesis.
  • This brain stem process is susceptible to migraine trigger factors.

Related Experiment Videos