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[Normal course of autoimmune thyroid disease in diabetic children]

V Rákosníková1, M Zahradníková, J Zikmund

  • 1Klinika dĕtí a dorostu 3. LF UK a FNKV, Praha.

Casopis Lekaru Ceskych
|July 5, 2003
PubMed

Insights

Autoimmune thyroid disease (AITD) affects 28% of children with Type 1 diabetes mellitus (T1DM). Severely elevated autoantibodies increase the risk of subclinical hypothyroidism, while mild elevations do not predict thyroid dysfunction.

Area of Science:

  • Pediatric Endocrinology
  • Immunology
  • Endocrinology

Context:

  • Type 1 diabetes mellitus (T1DM) is frequently associated with other autoimmune conditions.
  • Autoimmune thyroid disease (AITD) is the most common comorbidity in children with T1DM.

Purpose:

  • To determine the prevalence of AITD in children with T1DM.
  • To investigate the natural course of AITD in this pediatric cohort.

Summary:

  • AITD was diagnosed in 31% of 110 children with T1DM.
  • Mild elevations in thyroid autoantibodies (thyroglobulin autoantibodies [Ab-hTG] and/or peroxidase autoantibodies [Ab-TPO]) were not linked to thyroid morphology changes or dysfunction.
  • Severe elevations in Ab-hTG and/or Ab-TPO were associated with an increased risk of subclinical hypothyroidism and morphological changes in the thyroid gland.

Impact:

  • Identifies children with T1DM at higher risk for developing hypothyroidism.
  • Informs clinical monitoring and management strategies for pediatric patients with T1DM and AITD.
  • Highlights the importance of monitoring thyroid function in children with T1DM, particularly those with elevated autoantibody levels.
Abstract

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