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Updated: Sep 23, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Application of an ephedrine chiral linker in a solid-phase, 'asymmetric catch-release' approach to
Nessan J Kerrigan1, Panee C Hutchison, Tom D Heightman
1Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow, Scotland, UK G12 8QQ.
Abstract:
A Sm(II)-mediated, asymmetric, intermolecular ketyl-olefin addition employing alpha,beta-unsaturated esters linked to resin through an ephedrine 'chiral link' has been applied in a direct 'asymmetric catch-release' approach to gamma-butyrolactones.
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