Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Determination of insulin sensitivity: methodological considerations.

A A Starke1

  • 1Department of Nutrition and Metabolism, WHO Collaborating Centre for Diabetes, University of Düsseldorf, Germany.

Journal of Cardiovascular Pharmacology
|January 1, 1992
PubMed
Summary

Insulin resistance, a key feature of type II diabetes, is closely linked to obesity and hypertension. The euglycemic hyperinsulinemic clamp is the most reliable method for measuring insulin sensitivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulated postaggression metabolism in healthy subjects: metabolic changes and insulin resistance.

Metabolism: clinical and experimental·1998
Same author

Prandial glycaemia after a carbohydrate-rich meal in type I diabetic patients: using the rapid acting insulin analogue [Lys(B28), Pro(B29)] human insulin.

Diabetic medicine : a journal of the British Diabetic Association·1996
Same author

Time-action profile of the insulin analogue B28Asp.

Diabetic medicine : a journal of the British Diabetic Association·1996
Same author

Prospective study on the detection of insulinomas by endoscopic ultrasonography.

Endoscopy·1996
Same author

Time-action profiles of the intermediate-acting insulin analogue des(64,65)-human proinsulin.

Diabete & metabolisme·1995
Same author

Four week administration of an ACE inhibitor and a cardioselective beta-blocker in healthy volunteers: no influence on insulin sensitivity.

European journal of clinical investigation·1995

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Physiology

Background:

  • Type II diabetes is characterized by insulin resistance, unlike type I diabetes which involves defective insulin secretion.
  • Obesity and hypertension are frequently associated with insulin resistance, though causal links are still under investigation.
  • Certain medications, including diuretics and ACE inhibitors, can impact insulin sensitivity.

Purpose of the Study:

  • To highlight the growing need for accurate measurement of insulin sensitivity.
  • To discuss the complexities of quantifying insulin's various actions beyond glucose metabolism.
  • To present the euglycemic hyperinsulinemic clamp as the gold standard for assessing insulin action.

Main Methods:

  • The euglycemic hyperinsulinemic clamp technique is presented as the most reliable method for quantifying insulin action.

Related Experiment Videos

  • Integration with tracer methodology and calorimetry provides detailed insights into insulin's effects on target cells.
  • Focus is on measuring overall glucose uptake under controlled conditions.

    • Main Results:

    • The euglycemic hyperinsulinemic clamp technique meets both clinical and scientific requirements for measuring insulin sensitivity.
    • This method, combined with others, allows for a quantitative understanding of insulin action.
    • The extent to which insulin resistance affects actions beyond glucose metabolism is still an area of active research.

    Conclusions:

    • Accurate measurement of insulin sensitivity is crucial, particularly in the context of type II diabetes, obesity, and hypertension.
    • The euglycemic hyperinsulinemic clamp is the preferred method for assessing insulin action.
    • Further research is needed to fully understand the scope of insulin resistance in various physiological processes.