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Cobalt-mediated approach for the synthesis of terpene-based hybrids
Elsa Alvaro1, María C de la Torre, Miguel A Sierra
1Instituto de Química Orgánica, Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, 28006-Madrid, Spain.
Organic Letters
|July 5, 2003
Abstract:
[structure: see text] Dicobalt-beta-pinene hybrids of types I and II have been prepared using a Nicholas reaction between propargyl derivatives, obtained from commercial (1R)-(-)-myrtenal, and different aromatic nucleophiles. The method is suitable for the preparation of densely functionalized bio-organometallic natural product-based hybrids, as demonstrated by the preparation of a beta-pinene-neoclerodane hybrid.