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Regioselective [2 + 2 + 2] cycloaddition of a nickel-benzyne complex with 1,3-diynes
Kimberly R Deaton1, Mary S Gin
1Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Organic Letters
|July 5, 2003
Abstract:
[reaction: see text] Reactions of nickel(0)-benzyne complexes with a range of symmetrically substituted 1,3-diynes in the presence of triethylphosphine lead to the regioselective formation of 2,3-dialkynyl naphthalenes. The regioselectivity can be reversed when the diyne possesses substituents of high steric bulk, allowing selective formation of either symmetric dialkynyl naphthalene.