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Isotretinoin and psychiatric illness in adolescents and young adults

Shelly J Enders¹, Jason M Enders

¹Division of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO 63110-1088, USA. senders@stlcop.edu

The Annals of Pharmacotherapy

|July 5, 2003

Abstract

Objective:

To evaluate the relationship between isotretinoin and psychiatric illness in adolescents and young adults.

Data Sources:

Primary literature located via MEDLINE (1966-December 2002). Key terms were isotretinoin, depression, psychosis, suicide, and adolescents.

Data Synthesis:

Information regarding depression was added to isotretinoin labeling in 1998 following a series of case reports and submitted to the MedWatch system.

Conclusions:

Although a causal relationship may exist between isotretinoin and psychiatric illness in adolescents and young adults, this has not been demonstrated in the literature. Until evidence establishes a presence or lack of causality, prescribers should exercise caution when treating adolescents and young adults with isotretinoin.

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