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Increased bone mineral density in patients with chronic hypoparathyroidism
Fredriech K W Chan1, Sau-Cheung Tiu, Kin-Lam Choi
1Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, China. chankwf@netvigator.com
The Journal of Clinical Endocrinology and Metabolism
|July 5, 2003
Summary
Patients with hypoparathyroidism, both idiopathic and post-thyroidectomy, show increased bone mineral density (BMD), particularly in the lumbar spine. This finding suggests hypoparathyroidism is linked to higher BMD compared to the general population.
Area of Science:
- Endocrinology
- Bone Metabolism
- Mineral Disorders
Background:
- Postmenopausal females with post-thyroidectomy hypoparathyroidism exhibit increased bone mineral density (BMD).
- The effect of idiopathic hypoparathyroidism on BMD remains less understood.
Purpose of the Study:
- To investigate and compare BMD in patients with idiopathic hypoparathyroidism versus post-thyroidectomy hypoparathyroidism.
- To determine if idiopathic hypoparathyroidism is associated with similar BMD increases as seen in post-thyroidectomy hypoparathyroidism.
Main Methods:
- Dual-energy x-ray absorptiometry (DXA) was used to measure BMD.
- Lumbar spine and proximal femur BMD were assessed in 14 hypoparathyroid patients (8 idiopathic, 6 post-thyroidectomy).
- Patients were compared to age- and sex-matched controls.
Main Results:
- Patients with hypoparathyroidism demonstrated higher BMD than normal controls, with significant positive Z-scores at the lumbar spine (1.93 +/- 1.03) and femoral neck (1.14 +/- 0.62).
- No significant differences in BMD, T-score, or Z-score were found between the idiopathic and post-thyroidectomy hypoparathyroidism subgroups.
- Both groups showed elevated BMD, particularly in the lumbar spine.
Conclusions:
- Chronic hypoparathyroidism is associated with increased bone mineral density, especially in the lumbar spine.
- Idiopathic hypoparathyroidism leads to a comparable increase in BMD as post-thyroidectomy hypoparathyroidism.