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Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys.

Peter R Rapp1, John H Morrison, Jeffrey A Roberts

  • 1Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029-6574, USA. peter.rapp@mssm.edu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 5, 2003
PubMed
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Estrogen replacement therapy significantly improved spatial working memory in aged, surgically menopausal monkeys. Ovariectomy worsened learning deficits, highlighting ovarian hormones

Area of Science:

  • Neuroscience
  • Primate Cognition
  • Hormone Replacement Therapy

Background:

  • Cognitive function changes during postmenopause are not fully understood.
  • Estrogen's role in age-related cognitive decline requires further investigation.

Purpose of the Study:

  • To investigate the impact of surgical menopause and estrogen replacement on cognitive function in aged nonhuman primates.
  • To establish a primate model for studying estrogen's effects on cognitive aging.

Main Methods:

  • A controlled, prospective analysis was conducted on 16 aged rhesus monkeys.
  • Monkeys underwent ovariectomy, with half receiving cyclic estradiol replacement.
  • Neuropsychological assessments evaluated spatial working memory, recognition memory, and object discrimination learning.

Related Experiment Videos

Main Results:

  • Estrogen treatment reversed age-related spatial working memory impairments.
  • Modest improvements were noted in recognition memory tasks with estrogen.
  • Ovariectomy exacerbated age-related object discrimination learning deficits, irrespective of estrogen treatment.

Conclusions:

  • Ovarian hormone status broadly influences cognitive aging in primates, affecting multiple brain regions.
  • Estrogen replacement therapy shows potential in mitigating age-related cognitive decline.
  • This primate model facilitates research into the neurobiological mechanisms of estrogen's cognitive benefits.