Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Four-dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex.

Eugenius S B C Ang1, Tarik F Haydar, Vicko Gluncic

  • 1Department of Neurobiology, Yale Medical School, New Haven, Connecticut 06510, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 5, 2003
PubMed
Summary

GABAergic interneurons migrate to the neocortex from three distinct sources via independent streams. These neurons settle into specific cortical layers, guided by local cues, revealing precise areal and laminar deployment programs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Progenitor diversity during formation of the mammalian neocortex.

Frontiers in neuroscience·2026
Same author

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories.

Journal of anatomy·2026
Same author

Electronic Device Chargers in the Hospital: A Case Study.

The American journal of nursing·2026
Same author

The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets.

Journal of anatomy·2026
Same author

Lamination of primary visual cortex in the macaque: Layer 5 subdivisions.

Journal of anatomy·2026
Same author

Accomplishments of "Old-Fashioned" Electron Microscopy in the Period of Dominance of Immunofluorescent Methods.

International journal of molecular sciences·2026

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • GABAergic interneurons are crucial for cortical function.
  • Their precise migration and integration into the neocortex are essential for proper brain development.
  • Understanding interneuron migration is key to studying neurodevelopmental disorders.

Purpose of the Study:

  • To map the migration and settling patterns of GABAergic interneurons in the developing neocortex.
  • To identify the origins and migratory pathways of these interneurons.
  • To investigate the cues that guide their areal and laminar positioning.

Main Methods:

  • Time-lapse multiphoton microscopy was employed.
  • Imaging was performed on explant cultures and living mouse embryos.

Related Experiment Videos

  • The surface of cerebral hemispheres was analyzed to track cell movement.

    • Main Results:

    • GABAergic interneurons originate from three distinct sources in the ventral forebrain.
    • These interneurons migrate via separate and independent streams within the marginal zone.
    • Upon reaching their destination, interneurons descend to specific cortical layers, aligning with radially derived neurons.

    Conclusions:

    • The distinct migratory streams suggest selective responses to local cues for precise areal and laminar targeting.
    • Interneurons possess specific developmental programs for their deployment within the neocortex.
    • This study provides a new approach to investigate normal and abnormal neuronal migration.