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Updated: Sep 23, 2026
06:08
Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Melanin biosynthesis inhibitors from the bark of Machilus thunbergii
Gao Li1, Hye Kyung Ju, Hyuen Wook Chang
1College of Pharmacy, Yeungnam University, Gyongsan, Korea.
Biological & Pharmaceutical Bulletin
|July 5, 2003
Abstract:
The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC(50): 39.9, 15.1, 19.4 and 37.8 microM, respectively).
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