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Related Experiment Videos

Cataract extraction and cognitive function in older women.

Francine Grodstein1, Jennifer Chen, Susan E Hankinson

  • 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fran.grodstein@channing.harvard.edu

Epidemiology (Cambridge, Mass.)
|July 5, 2003
PubMed
Summary

This study found no link between cataract extraction and cognitive function or decline in older women. Oxidative stress may not be a shared factor in cataract and cognitive health.

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Area of Science:

  • Ophthalmology
  • Gerontology
  • Neurology

Background:

  • Oxidative damage is a key factor in cataract development.
  • Shared etiologic roles of oxidative stress may link cataract and other health conditions.

Purpose of the Study:

  • To investigate the relationship between cognitive function and cataract extraction.
  • To determine if oxidative stress plays a role in cognitive decline.

Main Methods:

  • 16,197 women aged 70-79 from the Nurses' Health Study were analyzed.
  • Cognitive function was assessed using six tests via telephone.
  • Logistic regression analyzed the association between cataract extraction and cognitive outcomes.

Main Results:

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  • No significant association was found between cataract extraction and low cognitive scores (RR = 0.99).
  • No significant association was observed between cataract extraction and substantial cognitive decline (RR = 1.08).

    • Conclusions:

    • Cataract extraction does not appear to be related to cognitive function in elderly women.
    • Findings suggest oxidative stress may not be a common pathway for cataract and cognitive impairment.