Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intraovarian regulation: the IGF-I example.

E Y Adashi1

  • 1Department of Obstetrics/Gynecology and Physiology, University of Maryland School of Medicine, Baltimore 21201.

Reproduction, Fertility, and Development
|January 1, 1992
PubMed
Summary

The intraovarian insulin-like growth factor (IGF) system amplifies gonadotropin action in the ovary. Future studies will determine if IGFs are essential for ovarian function through gene-specific ablation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Authors' reply re: Surrogacy: a family-building option in search of legitimacy.

BJOG : an international journal of obstetrics and gynaecology·2017
Same author

Ovulation-selective genes: the generation and characterization of an ovulatory-selective cDNA library.

The Journal of endocrinology·2006
Same author

Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor.

Placenta·2005
Same author

Amniotic fluid levels of immunoreactive monocyte chemotactic protein-1 increase during term parturition.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2003
Same author

Ovarian interleukin-1-induced gene expression: privileged genes threshold theory.

Medical hypotheses·2002
Same author

Interleukin 1 upregulates ovarian prostaglandin endoperoxide synthase-2 expression: evidence for prostaglandin-dependent/ceramide-independent transcriptional stimulation and for message stabilization.

Biology of reproduction·2001

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Molecular biology

Background:

  • Emerging evidence supports an intraovarian system of insulin-like growth factors (IGFs).
  • This system includes IGF ligands, receptors, and binding proteins within the ovary.

Purpose of the Study:

  • To investigate the role of the intraovarian IGF system in ovarian function.
  • To determine if IGFs are indispensable for normal ovarian activity.

Main Methods:

  • The study discusses the current understanding of the intraovarian IGF system.
  • Future research directions include selective ablation of ovarian IGF-I gene expression.

Main Results:

  • The intraovarian IGF system likely amplifies gonadotropin hormonal action.
  • Other regulatory roles of intraovarian IGFs are currently speculative.

Conclusions:

  • Further research is needed to establish the essentiality of IGFs for ovarian function.
  • Selective gene manipulation and reproductive potential assessment are key future steps.

Related Experiment Videos