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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

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Endothelium-dependent vasodilation is augmented by angiotensin converting enzyme inhibitors in healthy volunteers.

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Related Experiment Video

Updated: Jul 8, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

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Published on: March 30, 2018

Primary mediastinal diffuse large cell lymphoma initially presented with pericardial infiltration.

Y Uwabe1, H Yoshida, M Onishi

  • 1Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.

Internal Medicine (Tokyo, Japan)
|December 1, 1992
PubMed
Summary

A rare case of primary mediastinal diffuse large B-cell lymphoma presented with progressive dyspnea and cardiac tamponade. Prompt treatment involving pericardial drainage, thoracocentesis, and chemotherapy led to successful patient outcomes.

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Area of Science:

  • Oncology
  • Cardiology
  • Pathology

Background:

  • Primary mediastinal diffuse large B-cell lymphoma (PMBCL) is a rare non-Hodgkin lymphoma.
  • Mediastinal tumors can present with diverse symptoms, including those affecting the heart.

Observation:

  • A 33-year-old woman presented with progressive dyspnea.
  • Imaging revealed a mediastinal tumor and pericardial effusion, indicative of cardiac tamponade.
  • Ultrasound cardiography confirmed cardiac tamponade.

Findings:

  • Histological diagnosis of diffuse large B-cell lymphoma was confirmed via fine needle aspiration biopsy and immunohistochemistry.
  • The patient's symptoms were directly related to pericardial effusion caused by the mediastinal tumor.
  • Successful treatment involved emergency pericardial drainage, thoracocentesis, and chemotherapy.

Implications:

  • This case highlights the importance of considering lymphoma in the differential diagnosis of mediastinal masses presenting with cardiac complications.
  • Early diagnosis and multimodal treatment are crucial for favorable outcomes in rare lymphoma presentations.
  • Further research into the specific mechanisms of cardiac involvement in PMBCL may improve patient management.