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Updated: Aug 10, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
[Hereditary (dysplastic) diseases of the joints]
Abstract:
Using the intentional procedures to reveal systemic semantic interrelations between different phenomena that form the causative-sequential chain in joint diseases of dysplasia genesis and assuming the pathology theory laws as a basis, applying the methodologies of different interdisciplinary sciences and the technology of cognitive simulation, the conceptual model "joint dysplasia--dysplasia arthrosis" was developed. This model depicts the characteristic features of joint dysplasia. The use of the model permitted one to base and describe a group of inherited (depressional) diseases of joints as an independent scientific orthopedo-arthrological problem. The application of the conceptual model confirmed its high cognitive and reforming role. Using this model on a knee joint new syndromes of dysplasia have been described; the system of roentgenometric diagnosis of dysplasia anomalies and new methods of surgical intervention have been elaborated; the foundation has been laid of prophylactic surgery aimed at the exclusion or at the minimizing of the risk of gonarthrosis in persons suffering from different inherited syndromes.
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