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The effect of different apo(a) isoforms on plasminogen activation in black South African subjects
S R Choma1, M Alberts, H C Potgieter
1School of Health Science, University of the North, Polokwane (Pietersburg), South Africa.
Objective:
The present study evaluates the effect of different apolipoprotein(a) [apo(a)] isofroms on plasminogen activation.
Design:
A cross-sectional study.
Setting:
A rural village (Dikgale district) in the Northen Province of South Africa.
Subject:
A total of 90 apparently healthy subjects (64 females and 36 males) aged 43 to 67 years participated in the study.
Results:
The mean lipoprotein(a) [ Lp(a)] level in the subjects was 38.14 +/- 22.34 mg/dl. No association was found between Lp(a) isoforms. When the ratio of Lp(a):plasminogen was less then 1.3, a competitive inhibition was observed, but when the ratio exceeded 1.3, an uncompetitive inhibition was observed with all isoforms.
Conclusion:
The results of the present study suggest that the inhibition of plasminogen activation by Lp(a) is not dependent of apo(a) size.
