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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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Published on: April 16, 2012

[CD4(+)CD25(+) regulatory T cells and their function in maintaining transplantation tolerance]

Rui-Xiang Fu1, De-Pei Wu

  • 1The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Suzhou 215006, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 8, 2003
PubMed

This article reviews that as a functionally and phenotypically distict immunoregulatory T cell subpopulation, CD4(+)CD25(+) regulatory T cells can suppress the activation and proliferation of CD4(+)CD25(-) T cells and CD8(+) T cells and the production of IL-2 and IFN-gamma. These regulatory cells play an important role in allograft tolerance, although the mechanisms are not completely understood to date. CD4(+)CD25(+) regulatory T cells can be isolated, activated and expanded in vitro without loss of their immunoregulatory function. The suppressive function of activated CD4(+)CD25(+) cells is antigen non-specific. Ex vivo activated and expanded regulatory T cells have a perspective for practical use.

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