Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin B1 blocks damage caused by hyperglycemia.

Mark E Obrenovich1, Vincent M Monnier

  • 1Department of Pathology at Case Western Reserve University, Cleveland, OH 44106, USA. vmm3@po.cwru.edu

Science of Aging Knowledge Environment : SAGE KE
|July 8, 2003
PubMed
Summary

Benfotiamine, a vitamin B1 derivative, may prevent diabetes complications by activating transketolase. This vitamin derivative helps divert harmful metabolites, protecting against diabetic retinopathy and metabolic damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lens aging and disease: Molecular mechanisms, functional consequences, and pharmacological implications.

Progress in retinal and eye research·2026
Same author

A Novel Aberrant HbF Peak with Electrophoretic Shift in A1c of a Patient with Chronic Lymphocytic Leukemia (CLL) Was Reversible to Give Interpretable Results.

Biomedicines·2026
Same author

Consumption of processed foods impairs memory function through dietary advanced glycation end-products.

bioRxiv : the preprint server for biology·2026
Same author

Identification and Quantification by Targeted Metabolomics of Antibiotic-Responsive Urinary Small Phenolic Molecules Derived from the Intestinal Microbiota in Mice.

Pathogens & immunity·2025
Same author

Targeted and Non-Targeted Metabolomic Evaluation of Cerebrospinal Fluid in Early Phase Schizophrenia: A Pilot Study from the Hopkins First Episode Psychosis Project.

Metabolites·2025
Same author

Diabetes Endothelial Keratoplasty Study: Methods and Impact on the Use of Corneas From Donors With Diabetes for Descemet Membrane Endothelial Keratoplasty.

Cornea·2025

Area of Science:

  • Biochemistry
  • Endocrinology
  • Cell Biology

Background:

  • Diabetes accelerates aging and causes severe complications like blindness and cardiovascular disease.
  • High glucose levels in diabetes lead to mitochondrial dysfunction and damage to key enzymes like GAPDH.
  • This damage activates detrimental metabolic pathways: advanced glycation end-products, protein kinase C, and hexosamine pathways.

Purpose of the Study:

  • To investigate the potential of benfotiamine, a vitamin B1 derivative, in preventing diabetes-related metabolic damage.
  • To explore the mechanism by which benfotiamine might counteract hyperglycemia-induced cellular damage.

Main Methods:

  • Diabetic rats were treated with high doses of benfotiamine.
  • The study assessed the impact of benfotiamine on key metabolic pathways and diabetic complications, specifically retinopathy.

Related Experiment Videos

Main Results:

  • Benfotiamine treatment prevented diabetic retinopathy in rats.
  • It also prevented the activation of the three major metabolic damage pathways implicated in diabetes.
  • The protective effect was attributed to stimulated transketolase activity, which diverts metabolites to the pentose pathway.

Conclusions:

  • Benfotiamine shows promise in preventing diabetic complications and associated metabolic damage.
  • The findings suggest a therapeutic role for benfotiamine in managing diabetes, though further clinical data is needed.