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Related Experiment Videos

Creating new neurons in old brains.

Phyllis M Wise1

  • 1Department of Neurobiology, Physiology and Behavior, Division of Biological Sciences, University of California, Davis, Davis, CA 95616, USA. pmwise@ucdavis.edu

Science of Aging Knowledge Environment : SAGE KE
|July 8, 2003
PubMed
Summary
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Growth factors can stimulate neurogenesis in aged mice, reversing age-related declines. This finding suggests potential human therapies for maintaining brain function in old age.

Area of Science:

  • Neuroscience
  • Aging Research
  • Cell Biology

Background:

  • Aged rodent brains show reduced neurogenesis compared to younger adults.
  • Growth factors are known to boost neurogenesis in young rodents.
  • The effect of growth factors on neurogenesis in aging brains remains unclear.

Purpose of the Study:

  • To investigate if growth factors can stimulate neurogenesis in aged rodent brains.
  • To determine if treatments effective in young rodents are applicable to aging brains.

Main Methods:

  • Administration of two specific growth factors to aged mice.
  • Assessment of neurogenesis levels in the brains of treated aged mice.

Main Results:

  • The study found that two growth factors successfully stimulated neurogenesis in aged mice.

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  • This indicates that aging does not completely abolish the brain's capacity for neurogenesis in response to growth factors.

    • Conclusions:

    • Growth factor administration can enhance neurogenesis in the aging brain.
    • This research opens possibilities for therapeutic interventions to support cognitive function in elderly individuals.
    • Further research may explore similar treatments for human brain health maintenance in old age.