Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does anti-aging equal anti-microbial?

Gordon J Lithgow1

  • 1Buck Institute for Age Research, Novato, CA 94945, USA. glithgow@buckinstitute.org

Science of Aging Knowledge Environment : SAGE KE
|July 8, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-based screen identifies translation state modulators that extend lifespan in D. melanogaster and C. elegans.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

<i>Caenorhabditis</i> Intervention Testing Program: the anticonvulsant levetiracetam does not extend lifespan in nematodes.

microPublication biology·2026
Same author

Shifts in protein aggregate stability define proteostasis decline in the aging human brain.

bioRxiv : the preprint server for biology·2026
Same author

Coordination of Anle138b to Silver Results in Selective Reduction of a C-Terminal Truncated α-Synuclein Protein and Increased Aggregate Size.

ChemMedChem·2026
Same author

"Coordination of Anle138b to Silver Results in Selective Reduction of a C-terminal truncated Alpha-synuclein Protein and Increased Aggregate Size."

bioRxiv : the preprint server for biology·2025
Same author

Germline regulation of the intestinal mitochondrial unfolded protein response.

GeroScience·2025
Same journal

I come not to bury SAGE KE but to appraise It.

Science of aging knowledge environment : SAGE KE·2006
Same journal

Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment.

Science of aging knowledge environment : SAGE KE·2006
Same journal

From bedside to bench: does mental and physical activity promote cognitive vitality in late life?

Science of aging knowledge environment : SAGE KE·2006
Same journal

The unusual genetics of human longevity.

Science of aging knowledge environment : SAGE KE·2006
Same journal

A work in progress: the metabolic syndrome.

Science of aging knowledge environment : SAGE KE·2006
Same journal

WRN's tenth anniversary.

Science of aging knowledge environment : SAGE KE·2006
See all related articles

Longevity may be linked to a stronger immune system. Studies show that the insulin/insulin-like growth factor 1 (IGF-1) pathway influences aging and bacterial infection resistance in worms.

Area of Science:

  • Aging research
  • Immunology
  • Genetics

Background:

  • Aging is a primary risk factor for numerous diseases in developed nations.
  • A common underlying mechanism for diverse age-related diseases is hypothesized.
  • The insulin/insulin-like growth factor 1 (IGF-1) signaling pathway is a key regulator of aging.

Purpose of the Study:

  • To investigate the potential link between aging mechanisms and disease susceptibility.
  • To explore if common pathways regulate aging and innate immunity.
  • To determine if genetic longevity correlates with enhanced stress and infection resistance.

Main Methods:

  • Utilized the model organism Caenorhabditis elegans.
  • Investigated the role of insulin/IGF-1 signaling in aging and immunity.

Related Experiment Videos

  • Assessed bacterial resistance and stress resilience in long-lived worms.

    • Main Results:

    • Insulin/IGF-1 signaling was found to influence resistance to bacterial infection in C. elegans.
    • Long-lived worms exhibited increased stress resistance.
    • Long-lived worms showed delayed susceptibility to infection.

    Conclusions:

    • Genetically determined longevity may be associated with enhanced innate immunity.
    • The insulin/IGF-1 pathway plays a role in both aging and immune defense.
    • Findings suggest a potential common mechanism linking aging and disease resistance.