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Characterization of the human HOX 7 cDNA and identification of polymorphic markers
B J Padanilam1, H S Stadler, K A Mills
1Department of Biology, University of Iowa, Iowa City 52242.
Human Molecular Genetics
|September 1, 1992
Abstract:
cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified MboII and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.