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Sodium-dependent ascorbic acid transporter family SLC23.

Hitomi Takanaga1, Bryan Mackenzie, Matthias A Hediger

  • 1Membrane Biology Program and Renal Division, Brigham & Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Pflugers Archiv : European Journal of Physiology
|July 8, 2003
PubMed
Summary

Vitamin C transporters (SVCT1 and SVCT2) are crucial for cellular uptake. While SVCT1 is in epithelial systems, SVCT2 is vital for specialized tissues, though its exact roles require further investigation.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • l-Ascorbic acid (vitamin C) is a vital antioxidant and cofactor.
  • Two main transporters, Na(+)-dependent vitamin C transporters 1 and 2 (SVCT1 and SVCT2), facilitate vitamin C uptake.
  • These transporters belong to the SLC23 gene family, which includes orphan members.

Purpose of the Study:

  • To elucidate the distinct distribution and functions of SVCT1 and SVCT2.
  • To understand the essential roles of SVCT2 in various tissues.

Main Methods:

  • Analysis of transporter distribution.
  • Investigation using SVCT2-knockout mouse models.

Main Results:

  • SVCT1 is primarily located in epithelial systems (intestine, kidney, liver).

Related Experiment Videos

  • SVCT2 is found in specialized tissues like neurons, the eye, lung, and placenta.
  • SVCT2 knockout mice demonstrate its essential requirement, but specific functions remain partially understood.

    • Conclusions:

    • SVCT1 and SVCT2 exhibit distinct tissue-specific expression patterns.
    • SVCT2 is indispensable for certain physiological processes, necessitating further research into its precise functions.