Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic science priorities for therapeutics research.

Sandra Bridges

    Research Initiative, Treatment Action : RITA
    |July 9, 2003
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Humanized immune system mouse models: progress, challenges and opportunities.

    Nature immunology·2019
    Same author

    Highlights from the Fourth Biennial Strategies for an HIV Cure Meeting, 10-12 October 2018, Bethesda, MD, USA.

    Journal of virus eradication·2019
    Same journal

    The road to a cure.

    Research initiative, treatment action : RITA·2007
    Same journal

    Plumbing HIV pathogenesis.

    Research initiative, treatment action : RITA·2007
    Same journal

    Women and HIV: a global inequality.

    Research initiative, treatment action : RITA·2007
    Same journal

    HIV vaccines: the future looks promising.

    Research initiative, treatment action : RITA·2007
    Same journal

    Thou shall not bear silent witness: the role of international activism in HIV.

    Research initiative, treatment action : RITA·2007
    Same journal

    HIV controllers: an untapped source of clues to overcoming HIV infection.

    Research initiative, treatment action : RITA·2007
    See all related articles

    Highly active antiretroviral therapy (HAART) for HIV has limitations due to drug resistance and toxicity. New therapeutic strategies, including vaccines and novel drug targets, are urgently needed to improve HIV treatment outcomes.

    Area of Science:

    • Virology
    • Immunology
    • Pharmacology

    Background:

    • For over a decade, HIV drug discovery focused on reverse transcriptase (RT) and protease (PR) inhibitors.
    • Highly active antiretroviral therapy (HAART) reduces viral load but faces challenges from drug resistance and poor adherence.
    • Existing treatments only partially restore immune function damaged by HIV.

    Purpose of the Study:

    • To highlight the urgent need for novel therapeutic strategies against HIV.
    • To identify new host and viral targets for drug development.
    • To explore immunologic approaches complementing drug therapies.

    Main Methods:

    • Review of current HIV treatment landscape and limitations.
    • Identification of emerging drug classes targeting viral entry.

    Related Experiment Videos

  • Emphasis on the role of vaccination and innate immunity.

    • Main Results:

    • Drug resistance and regimen toxicity remain significant hurdles in HIV treatment.
    • New agents targeting viral binding and entry are in development.
    • Immune system damage from HIV is not fully reversed by HAART.

    Conclusions:

    • There is a critical need for new host and viral targets, novel drugs, and delivery systems.
    • Immunologic approaches, including vaccines, are essential to complement drug therapy.
    • Research priorities include host/viral targets, inhibitors, vaccines, innate immunity, viral reservoirs, and gene therapy.