[Solid phase synthesis and chromatographic characteristics of nucleophilic agents conjugated with oligonucleotides
A V Kachalova1, V N Tashlitskiĭ, D A Stetsenko
1Faculty of Chemistry, Belozersky Institute of Physicochemical Biology, Lomonosov State University, Vorob'evy gory, Moscow, 119992 Russia.
Abstract:
Conjugates of amines or short peptides with oligonucleotides containing 5'-terminal carboxyl group were prepared by solid phase chemical synthesis. A correlation between the physicochemical parameters and retention times of the synthesized conjugates was established by ion-pair reversed-phase HPLC.
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