Related Experiment Video
Updated: Sep 23, 2026
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
No therapeutic effect of plasmin antagonist tranexamic acid in rheumatoid arthritis. A double-blind
W H van der Laan1, H K Ronday, J M TeKoppele
1Division of Vascular and Connective Tissue Research, Gaubius Laboratory, TNO Prevention and Health, Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Objective:
In the present study, the effects of plasmin antagonist tranexamic acid (TEA) on urinary pyridinoline excretion rates were investigated in rheumatoid arthritis (RA) patients.
Methods:
The study was set up as a double-blind placebo-controlled pilot study. Ten patients received tranexamic acid and 9 received placebo for 12 weeks. Urinary excretion rates of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) were used as molecular markers of articular cartilage and bone degradation. In addition, clinical parameters of disease activity were assessed and CRP levels were measured.
Results:
Treatment with TEA did not reduce pyridinoline excretion, nor was any effect observed on clinical parameters of disease activity or on CRP levels.
Conclusion:
The results of the present pilot study show no beneficial effect of TEA as adjuvant therapy in RA patients with respect to joint destruction or disease activity.