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Making PROGRESS in stable patients post stroke or transient ischaemic attack: implications for general practice

G Jackson1

  • 1Cardiothoracic Centre, St Thomas' Hospital, London, UK.

International Journal of Clinical Practice
|July 9, 2003
PubMed

Insights

The PROGRESS trial found that perindopril significantly reduces the risk of recurrent stroke, cardiovascular events, and heart failure in patients with a history of stroke or TIA. This blood pressure-lowering treatment is recommended for stable post-stroke patients.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Stroke is a leading cause of death and disability.
  • Survivors face a high risk of subsequent strokes within five years.
  • Effective secondary prevention strategies are crucial.

Purpose of the Study:

  • To evaluate the efficacy of blood pressure lowering with perindopril in preventing recurrent cerebrovascular and cardiovascular events.
  • To assess the impact of perindopril on stroke, cardiovascular events, and heart failure in patients with a history of stroke or transient ischaemic attack (TIA).

Main Methods:

  • The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a specific clinical trial.
  • Investigated hypertensive and non-hypertensive patients with prior stroke or TIA.
  • Assessed outcomes with perindopril-based treatment versus placebo.

Main Results:

  • Perindopril significantly reduced the risk of stroke by 28%.
  • Cardiovascular events were reduced by 26% with perindopril treatment.
  • Heart failure incidence decreased by 26% in the perindopril group.

Conclusions:

  • Perindopril offers significant benefits in secondary stroke prevention.
  • Recommended for stable post-stroke patients, potentially combined with indapamide and other evidence-based treatments.
  • Therapy initiation and monitoring can occur in outpatient or general practice settings.

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