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Making decisions for structural genomics.

Ana Rodrigues¹, Roderick E Hubbard

¹Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, UK. rodrigues@ysbl.york.ac.uk

Briefings in Bioinformatics

|July 9, 2003

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Structural genomics programs aim for high-throughput protein structure determination. This paper details bioinformatics tools and principles for selecting optimal protein targets to maximize structural information gained from experimental methods.

Area of Science:

Biochemistry
Structural Biology
Bioinformatics

Background:

Structural genomics initiatives aim for large-scale, high-throughput protein structure determination.
Experimental methods like X-ray crystallography and NMR spectroscopy face challenges, necessitating careful target selection.
Prioritizing molecules is crucial to maximize information from each determined protein structure.

Purpose of the Study:

To outline the scientific principles guiding target selection in structural genomics.
To review bioinformatics tools applicable to protein target selection.
To describe the design and application of a dedicated resource for structural genomics target selection.

Main Methods:

Review of scientific principles for target selection in structural genomics.

Related Experiment Videos

Identification and discussion of relevant bioinformatics tools.

Description of a purpose-built resource for target selection.

Main Results:

The paper elucidates the scientific basis for selecting protein targets in structural genomics.
It highlights various bioinformatics tools that can aid in this selection process.
A specific resource designed for structural genomics target selection is presented.

Conclusions:

Effective target selection is critical for the success of structural genomics programs.
Bioinformatics tools play a vital role in optimizing the selection of protein targets.
The described resource offers a practical solution for enhancing structural genomics efforts.