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Anaesthetic management of the child with sickle cell disease

Warwick A Marchant1, Isabeau Walker

  • 1Great Ormond Street Hospital for Children, London, UK. warwick.marchant@virgin.net

Paediatric Anaesthesia
|July 9, 2003
PubMed

Insights

Sickle cell disease (SCD) is a common inherited blood disorder impacting children. This review covers SCD

Area of Science:

  • Hematology
  • Pediatrics
  • Genetics

Background:

  • Sickle cell disease (SCD) is a prevalent inherited hemoglobinopathy.
  • It causes substantial illness and death, particularly in pediatric populations.
  • Understanding SCD's genetic basis and clinical impact is crucial.

Purpose of the Study:

  • To review the epidemiology and pathophysiology of sickle cell disease.
  • To outline the clinical manifestations of SCD in children.
  • To discuss evidence-based perioperative management strategies for pediatric SCD patients.

Main Methods:

  • Literature review of epidemiological data.
  • Synthesis of current knowledge on SCD pathophysiology.
  • Analysis of clinical studies and guidelines on pediatric SCD management.

Main Results:

  • SCD affects numerous children globally, with diverse clinical presentations.
  • Pathophysiology involves abnormal hemoglobin leading to red blood cell sickling.
  • Perioperative care requires specific protocols to mitigate risks.

Conclusions:

  • Comprehensive understanding of SCD is vital for effective pediatric care.
  • Tailored perioperative management is essential for improving outcomes in children with SCD.
  • Further research can refine management guidelines.

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