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Cerebral abscesses due to Pseudomonas pseudomallei.

V Kasantikul1, S Lerdlum, N Suwanwela

  • 1Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|September 1, 1992
PubMed
Summary

Cerebral melioidosis, caused by Pseudomonas pseudomallei, presents as brain abscesses. Early diagnosis and prompt treatment with antibiotics like ceftazidime are crucial for managing this potentially fatal infection.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Background:

  • Melioidosis is a serious infectious disease caused by the bacterium Pseudomonas pseudomallei.
  • Cerebral involvement, or melioidosis, can lead to the formation of brain abscesses.

Observation:

  • Two cases of cerebral abscesses due to Pseudomonas pseudomallei are presented.
  • One patient, a 51-year-old woman, experienced rapid neurological decline and disseminated infection.
  • A 9-year-old boy presented with isolated cerebral abscesses and recovered with ceftazidime treatment.

Findings:

  • A review of ten cerebral melioidosis cases showed it affects all ages, predominantly men.
  • The frontoparietal lobe was the most common site for abscesses.
  • Common symptoms include fever, headache, and hemiparesis; seizures and ataxia are less common.

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Implications:

  • Computed tomography (CT) scanning, serum antibody titers, and hemoculture are valuable diagnostic tools.
  • Early diagnosis and prompt antibiotic treatment are vital for improving outcomes in cerebral melioidosis.
  • This condition, though fatal, is treatable with timely medical intervention.