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Bone marrow angiogenesis and circulating plasma cells in multiple myeloma
Shaji Kumar1, Thomas E Witzig, Philip R Greipp
1Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA. rajks@mayo.edu
British Journal of Haematology
|July 9, 2003
Summary
Increased bone marrow (BM) angiogenesis in multiple myeloma (MM) correlates with more circulating plasma cells (PCs). This suggests angiogenesis may drive cancer spread and indicate a poorer prognosis for MM patients.
Area of Science:
- Oncology
- Hematology
- Angiogenesis Research
Background:
- Bone marrow (BM) angiogenesis is elevated in multiple myeloma (MM) and linked to patient outcomes.
- The presence of circulating plasma cells (PCs) in MM signifies a worse prognosis.
Purpose of the Study:
- To investigate the relationship between angiogenesis and circulating plasma cells (PCs) in newly diagnosed multiple myeloma (MM).
- To correlate microvessel density (MVD) with the number of circulating PCs in MM patients.
Main Methods:
- Analysis of BM biopsies from MM patients at diagnosis.
- Quantification of microvessel density (MVD) in BM biopsies.
- Correlation of MVD with the absolute number of circulating PCs.
Main Results:
- A positive correlation was found between the absolute number of circulating PCs and mean MVD in the BM.
- This association remained significant regardless of disease activity or PC burden within the marrow.
Conclusions:
- Increased angiogenesis in the bone marrow of MM patients is linked to a higher number of circulating PCs.
- Enhanced angiogenesis may facilitate plasma cell proliferation and their dissemination into the bloodstream, contributing to disease progression.