Jove
Visualize
Contact Us

Related Experiment Videos

[Perioperative blood coagulation problems in children].

A M Mingers1

  • 1Universitäts-Kinderklinik Würzburg, BRD.

Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1992
PubMed
Summary

Pediatric preoperative coagulation screening requires more than just aPTT and Quick tests to detect disorders like von Willebrand disease. Comprehensive testing is crucial for accurate diagnosis in children.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homozygous and compound-heterozygous type I plasminogen deficiency is a common cause of ligneous conjunctivitis.

Thrombosis and haemostasis·2001
Same author

Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

Blood·1999
Same author

Human homozygous type I plasminogen deficiency and ligneous conjunctivitis.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·1999
Same author

Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis.

Seminars in thrombosis and hemostasis·1999
Same author

Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.

The New England journal of medicine·1998
Same author

Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

Blood·1997
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Pediatric Hematology
  • Hemostasis and Thrombosis

Context:

  • Childhood preoperative coagulation diagnosis is essential for identifying bleeding disorders.
  • Neonatal coagulation differs significantly from adult coagulation.
  • Standard screening may miss critical conditions like von Willebrand disease.

Purpose:

  • To highlight the limitations of reduced coagulation screening in pediatric patients.
  • To emphasize the importance of comprehensive hemostaseological evaluation.
  • To discuss specific pediatric coagulation challenges, including von Willebrand disease and lupus inhibitors.

Summary:

  • Current pediatric preoperative coagulation screening, often limited to activated partial thromboplastin time (aPTT) and Quick test, inadequately identifies severe hemostaseological disorders.
  • Conditions like von Willebrand disease, common in children, can present with normal aPTT values, necessitating broader diagnostic approaches.
  • Temporary aPTT prolongations in children with adenoid hypertrophy may indicate lupus inhibitors, further complicating diagnosis with limited testing.

Impact:

  • Advocates for more thorough coagulation testing in pediatric preoperative evaluations.
  • Aims to improve diagnostic accuracy for bleeding disorders in children.
  • Informs clinical practice regarding the nuances of pediatric hemostasis and the management of coagulation factor deficiencies.

Related Experiment Videos