Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hepatic encephalopathy. Pathogenesis and therapy].

F M Felaco1, P Pagliano

  • 1Istituto di Malattie Tropicali e Subtropicali, II Universita degli Studi di Napoli.

Le Infezioni in Medicina
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of viral pneumonia in the COVID-19 era: an update.

Infection·2021
Same author

Clinical and prognostic features of prosthetic joint infections caused by Enterococcus spp.

European review for medical and pharmacological sciences·2019
Same author

Post-arthroscopic septic arthritis of the knee. Analysis of the outcome after treatment in a case series and systematic literature review.

European review for medical and pharmacological sciences·2019
Same author

ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

RELEASE OF GENTAMICIN FROM CEMENT SPACERS IN TWO-STAGE PROCEDURES FOR HIP AND KNEE PROSTHETIC INFECTION: AN IN VIVO PHARMACOKINETIC STUDY WITH CLINICAL FOLLOW-UP.

Journal of biological regulators and homeostatic agents·2016
Same author

The clinical features, diagnosis, treatment, and prognosis of neuroinvasive listeriosis: a multinational study.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2015
Same journal

Rezafungin and catheter-related candidemia: a new player in a high-stakes game.

Le infezioni in medicina·2026
Same journal

Effectiveness and Safety Profile of BIC/TAF/FTC in People living with HIV Switched from Other Antiretroviral Regimens: A Real-Life Retrospective Cohort Analysis.

Le infezioni in medicina·2026
Same journal

Insights into parvovirus B19 clinical and virological dynamics among blood donors.

Le infezioni in medicina·2026
Same journal

When Faster Diagnosis Is Not Enough: Bringing Diagnostic Stewardship into Antimicrobial Stewardship.

Le infezioni in medicina·2026
Same journal

Fragility of Immunisation and Water Systems in Gaza: Infectious Disease Risks in a Conflict-Affected Setting.

Le infezioni in medicina·2026
Same journal

HIV-2 infection in Europe - persistence by migrant flows from West Africa but low spillover into the native population.

Le infezioni in medicina·2026
See all related articles

Hepatic encephalopathy, a complication of cirrhosis, involves elevated ammonia and altered neurotransmitters. Treatment focuses on reducing ammonia and correcting brain function abnormalities.

Area of Science:

  • Hepatology
  • Neuroscience
  • Biochemistry

Context:

  • Hepatic encephalopathy (HE) is a common complication in patients with cirrhosis.
  • It is characterized by neurological dysfunction due to liver failure and portal-systemic shunting.
  • Elevated ammonia levels are a hallmark of HE, impacting cerebral function.

Purpose:

  • To elucidate the biochemical and neurotransmitter alterations in hepatic encephalopathy.
  • To understand the mechanisms linking ammonia metabolism to neurological deficits.
  • To outline therapeutic strategies for managing hepatic encephalopathy.

Summary:

  • Cirrhosis leads to portal-systemic shunts and impaired liver function, causing elevated ammonia levels.
  • Ammonia detoxification via glutamine synthesis depletes ATP and glutamate, affecting neurotransmission.

Related Experiment Videos

  • Reduced branched-chain amino acids facilitate aromatic amino acid entry into the brain, altering neurotransmitter synthesis.
  • Benzodiazepine-like substances may also disrupt GABA-ergic transmission.

    • Impact:

    • Understanding these mechanisms aids in developing targeted therapies for hepatic encephalopathy.
    • Correcting ammonia levels and neurotransmission abnormalities can improve patient outcomes.
    • This research contributes to managing the neurological complications of liver disease.