Related Experiment Video
Updated: Aug 7, 2026
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
Mesothelioma: Drug treatment and other interventions
Abstract:
Malignant mesothelioma was reported to be a tumor of the pleura for which there is no satisfactory treatment. It was also reported to be almost universally fatal, regardless of the stage of the tumor at the time of diagnosis. Due to the dismal prognosis for patients with this malignant disease, a new mode of treatment is desperately needed. Current drugs and other interventional modalities which include surgery, chemotherapy and radiation therapy are discussed below. However, in some patients none of these modalities are superior to absence of treatment. Discussed within this article are single agent and combined chemomodality therapy studies, target ligands, radiation-sensitizing and antiviral agents, multimodality and gene therapy, and chemoresistance.
Insights
Malignant mesothelioma, a fatal pleural tumor, lacks effective treatments. This review explores novel therapeutic strategies including gene therapy and targeted agents to improve patient outcomes.
Area of Science:
- Oncology
- Thoracic Surgery
- Medical Oncology
Background:
- Malignant mesothelioma is a rare and aggressive cancer originating in the pleura.
- Current treatment options offer limited efficacy and a poor prognosis for patients.
Purpose of the Study:
- To review existing and emerging treatment modalities for malignant mesothelioma.
- To highlight the urgent need for innovative therapeutic approaches.
Main Methods:
- Comprehensive literature review of current therapeutic strategies.
- Discussion of single-agent and combination therapies.
- Exploration of novel approaches like gene therapy and targeted ligands.
Main Results:
- Standard treatments (surgery, chemotherapy, radiation) show limited success.
- Emerging therapies including targeted agents, radiation sensitizers, and gene therapy show promise.
- Chemoresistance remains a significant challenge in treatment.
Conclusions:
- There is a critical need for novel treatment strategies for malignant mesothelioma.
- Multimodality and gene-based therapies represent promising avenues for future research.
- Addressing chemoresistance is essential for improving patient survival.
More Related Videos
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
07:54Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Related Concept Videos
02:17The Tumor Microenvironment
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against specific...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:56Treatment Resistent Cancers
01:27Tumor Immunotherapy