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Related Experiment Videos

Prostate specific antigen reference ranges in Saudi men.

Baher A Kamal1, Gaber A Ali, Saud A Taha

  • 1Department of Urology, College of Medicine, Kingdom of Saudi Arabia. drbaherkamal@yahoo.com

Saudi Medical Journal
|July 9, 2003
PubMed
Summary

This study establishes age-specific normal prostate-specific antigen (PSA) levels for Saudi men, revealing lower mean PSA values compared to other populations. These findings are crucial for accurate prostate cancer screening in Saudi Arabia.

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Area of Science:

  • Urology
  • Oncology
  • Biochemistry

Background:

  • Prostate-specific antigen (PSA) is a key biomarker for prostate health.
  • Establishing population-specific normal ranges is vital for accurate diagnostic interpretation.
  • Previous studies have not comprehensively defined age-specific PSA values for Saudi men.

Purpose of the Study:

  • To determine age-specific and population-specific normal values of prostate-specific antigen (PSA) in Saudi men.
  • To establish reference ranges for PSA in Saudi men aged 40-89 years.
  • To investigate potential racial variations in PSA levels.

Main Methods:

  • A cross-sectional study involving 567 cancer-free Saudi men aged 40-89 years.
  • Measurement of total and free PSA levels.

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  • Stratification into five 10-year age groups for analysis.

    • Main Results:

    • Mean total PSA values ranged from 0.87 ng/ml (40-49 years) to 2.36 ng/ml (80-89 years).
    • Percent free PSA remained above 30% across all age groups.
    • Upper limits of normal PSA were found to be lower than previously reported for some Asian populations.

    Conclusions:

    • Normal mean PSA values for Saudi men are lower than reported international values.
    • The percent free PSA threshold of <4 ng/ml is applicable in this population.
    • Observed racial variations in PSA levels highlight the need for population-specific reference ranges.