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Updated: Sep 23, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
Dilated cardiomyopathy due to endocrine dysfunction
Dulce Brito1, Mónica Pedro, Alvaro Bordalo
1Serviço de Cardiologia e Ginecologia-Obstetrícia, Hospital de Santa Maria, Lisboa.
Insights
Peripartum heart failure can stem from treatable conditions like hypothyroidism. Prompt treatment of hypothyroidism and hypocalcemia significantly improved cardiac function in a complex case.
Area of Science:
- Cardiology
- Endocrinology
Background:
- Dilated cardiomyopathy presents with diverse etiologies, including idiopathic and secondary causes.
- Peripartum cardiomyopathy is a specific form of heart failure occurring around childbirth.
Observation:
- A complex case of peripartum heart failure was identified.
- The patient presented with concurrent hypothyroidism and hypoparathyroidism.
Findings:
- Myocardial biopsy indicated hypothyroidism as the primary driver of the dilated cardiomyopathy.
- Severe hypocalcemia critically exacerbated heart failure during hospitalization.
Implications:
- This case highlights the importance of investigating endocrine disorders in peripartum heart failure.
- Timely correction of hypothyroidism and hypocalcemia can lead to substantial recovery of cardiac function.
Abstract:
Dilated cardiomyopathy can be idiopathic or be caused by many potentially treatable conditions. We report a complex case of peripartum heart failure associated with hypothyroidism and hypoparathyroidism. Myocardial biopsy suggested that hypothyroidism was the main cause for the dilated pattern, but hypocalcemia played a critical role in acute decompensation of heart failure during hospitalization. After a long and clinically complicated hospital stay, correction of hypothyroidism and hypocalcemia resulted in near-normal cardiac function.
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