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Effects of hemorheological factors on the development of hypertension in diabetic children

Halit Cam1, Kenan Püşüroğlu, Ahmet Aydin

  • 1Department of Pediatrics, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey. HACAM@ist.edu.tr

Journal of Tropical Pediatrics
|July 10, 2003
PubMed

Insights

Hypertension in diabetic children is linked to higher blood viscosity and fibrinogen levels, independent of diabetes control. These factors may also contribute to hypertension in obese children, suggesting a common pathway.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Cardiovascular Research

Background:

  • Diabetic children often exhibit elevated blood pressure.
  • Understanding hypertension pathogenesis in pediatric diabetes is crucial.

Purpose of the Study:

  • To investigate hemorheological factors influencing hypertension in diabetic children.
  • To compare blood pressure and hemorheological parameters in diabetic, obese, and healthy children.

Main Methods:

  • Measured arterial blood pressures in 46 diabetic children and compared them with 29 non-obese and 32 obese children.
  • Assessed blood viscosity, plasma viscosity, serum viscosity, serum albumin, and plasma fibrinogen.
  • Utilized multivariate discriminant analysis to identify key variables.

Main Results:

  • Diabetic children showed higher systolic and diastolic blood pressure than non-obese children.
  • Elevated blood viscosity, plasma viscosity, serum viscosity, serum albumin, and plasma fibrinogen correlated with higher blood pressure in diabetics.
  • Plasma viscosity and fibrinogen were identified as key predictors of hypertension.

Conclusions:

  • Diabetic children have elevated arterial blood pressure irrespective of diabetes control or lipid profiles.
  • Plasma viscosity and fibrinogen are primary determinants of hypertension in diabetic children.
  • Obesity and diabetes may share common mechanisms in hypertension development.

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