Related Experiment Videos
n-3 long-chain FA decrease serum levels of TG and remnant-like particle-cholesterol in humans.
Kei Hamazaki1, Miho Itomura, Mingming Huan
1Department of Clinical Application, Institute of Natural Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama-shi, Toyama 930-0194, Japan.
Lipids
|July 10, 2003
Summary
Omega-3 fatty acids (n-3 FA) supplementation significantly reduced triglyceride (TG) and remnant-like particle (RLP) cholesterol levels in hypertriglyceridemic patients. This suggests n-3 FA may offer anti-atherosclerotic benefits.
Area of Science:
- Cardiovascular Health
- Nutritional Science
- Biochemistry
Background:
- Hypertriglyceridemia is a risk factor for cardiovascular disease.
- n-3 fatty acids (n-3 FA) are known to reduce serum triglyceride (TG) levels.
- The impact of n-3 FA on remnant-like particle (RLP) cholesterol is less understood.
Purpose of the Study:
- To investigate the effect of n-3 FA supplementation on serum TG and RLP cholesterol concentrations.
- To evaluate the potential anti-atherosclerotic effects of n-3 FA in hypertriglyceridemic individuals.
Main Methods:
- A double-blind, randomized controlled trial involving 41 volunteers with TG levels between 100-300 mg/dL.
- The n-3 FA group received 125 mL of fermented soybean milk with fish oil (600 mg EPA, 260 mg DHA) daily for 12 weeks.
- The control group consumed control soybean milk with olive oil.
Main Results:
- n-3 FA supplementation significantly decreased TG levels at 4, 8, and 12 weeks (P < 0.05).
- RLP cholesterol levels were significantly reduced in the n-3 FA group at 8 and 12 weeks (P < 0.05).
- EPA concentrations in red blood cells increased significantly in the n-3 FA group.
Conclusions:
- n-3 long-chain fatty acids, even at a dose of 860 mg/d, can effectively lower serum TG and RLP-cholesterol.
- These findings suggest that n-3 FA may exert anti-atherosclerotic effects by improving lipid profiles.