Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphocyte function in patients with Hodgkin's disease.

H Rühl, W Vogt, U Rühl

    Giornale Di Batteriologia, Virologia Ed Immunologia
    |January 1, 1975
    PubMed
    Summary

    Patients with Hodgkin's disease show impaired lymphocyte stimulation and mixed lymphocyte reactions in vitro. However, their ability to produce a specific chemotactic factor remains largely unaffected.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Numerical investigation of a recent radiation reaction model and comparison to the Landau-Lifschitz model.

    Physical review. E·2025
    Same author

    Fibrinogen Bonn (p. Arg510Cys) in the Aα-Chain Is Associated with High Risk of Venous Thrombosis.

    Hamostaseologie·2023
    Same author

    [Perioperative management of coagulation in otorhinolaryngologic surgery].

    HNO·2022
    Same author

    Proton Bunch Self-Modulation in Plasma with Density Gradient.

    Physical review letters·2021
    Same author

    Experimental Observation of Proton Bunch Modulation in a Plasma at Varying Plasma Densities.

    Physical review letters·2019
    Same author

    Experimental Observation of Plasma Wakefield Growth Driven by the Seeded Self-Modulation of a Proton Bunch.

    Physical review letters·2019

    Area of Science:

    • Immunology
    • Oncology
    • Cellular Biology

    Background:

    • Hodgkin's disease is a malignancy affecting the lymphatic system.
    • Immune system dysregulation is a known characteristic of Hodgkin's disease.
    • Understanding specific lymphocyte function deficits is crucial for disease management.

    Purpose of the Study:

    • To investigate in vitro lymphocyte functions in patients diagnosed with Hodgkin's disease.
    • To assess the impact of Hodgkin's disease on key immune responses, including lymphocyte stimulation and cell-mediated immunity.

    Main Methods:

    • In vitro testing of lymphocyte functions.
    • Phytohemagglutinin (PHA)-induced lymphocyte stimulation assays.
    • One-way mixed lymphocyte culture (MLC) reactions.
    • Measurement of PHA-induced human mononuclear leukocyte chemotactic factor production.

    Main Results:

    • A significant depression in PHA-induced lymphocyte stimulation was observed in patients.
    • The responding capacity in one-way mixed lymphocyte culture reactions was severely impaired.
    • Conversely, PHA-induced production of a human mononuclear leukocyte chemotactic factor was not significantly altered.

    Conclusions:

    • Hodgkin's disease severely impairs certain in vitro lymphocyte functions, particularly T-cell mediated responses.
    • Specific immune functions, such as chemotactic factor production, may remain preserved despite the disease.
    • These findings highlight a selective immune defect in Hodgkin's disease, impacting cellular immunity.

    Related Experiment Videos