Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proinsulin-a pathogenic autoantigen in type 1 diabetes.

Parth Narendran1, Stuart I Mannering, Leonard C Harrison

  • 1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050 Parkville, Australia.

Autoimmunity Reviews
|July 10, 2003
PubMed
Summary

Proinsulin is identified as a key autoantigen in type 1 diabetes (T1D), triggering the immune response that destroys insulin-producing cells. This finding suggests proinsulin could be used therapeutically to prevent T1D.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed maturation of the milk microbiome in women with type 1 diabetes.

Diabetologia·2026
Same author

Early-stage type 1 diabetes: is there a role for lifestyle modifications?

The lancet. Diabetes & endocrinology·2026
Same author

Advancing Early-Stage Type 1 Diabetes Care: Future Focused Pathways for Identification, Screening, Diagnosis, and Monitoring.

Diabetes, obesity & metabolism·2026
Same author

Psychosocial implications, acceptability and ethics of screening for paediatric type 1 diabetes: a systematic review and mixed methods evidence synthesis.

Diabetologia·2026
Same author

Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD).

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

Effect of breaking up sitting with regular active breaks on glucose management and vascular function in adults with type 1 diabetes who use hybrid closed-loop insulin delivery systems: a randomised crossover trial protocol.

BMJ open sport & exercise medicine·2026

Area of Science:

  • Immunology
  • Endocrinology
  • Autoimmune Diseases

Background:

  • Type 1 diabetes (T1D) is an autoimmune condition characterized by immune system attacks on pancreatic beta cells.
  • This immune response leads to insulin deficiency, hyperglycemia, and the destruction of beta cells by autoantigens.

Purpose of the Study:

  • To evaluate proinsulin as a pathogenic autoantigen in type 1 diabetes (T1D) using established criteria.
  • To explore the potential of proinsulin as an immunotherapeutic target for T1D prevention.

Main Methods:

  • Review and application of criteria for autoantigen pathogenicity.
  • Examination of existing evidence linking proinsulin to the autoimmune response in T1D.

Main Results:

Related Experiment Videos

  • Proinsulin meets the defined criteria for a pathogenic autoantigen in type 1 diabetes.
  • Evidence supports proinsulin's role in eliciting the pathological immune responses observed in T1D.

    • Conclusions:

    • Proinsulin is confirmed as a significant autoantigen in type 1 diabetes.
    • Proinsulin presents a promising avenue for developing immunotherapies aimed at preventing T1D.