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Updated: Sep 23, 2026

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
Published on: December 16, 2021
Modifications of arginines and their role in autoimmunity
M A M van Boekel1, W J van Venrooij
1Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands. m.vanboekel@ncmls.kun.nl
Abstract:
Posttranslational modifications of proteins often perform a key role in the biological functioning of proteins. Some of these modifications also change the immunogenicity of proteins and peptides and create 'self'-antigens which might induce autoimmune responses. In particular modifications of arginines within a defined protein context can lead to a specific B-cell immune response. This review discusses the generation of such modifications and their relevance for autoimmunity.
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