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Antiphospholipid syndrome: pathogenic mechanisms.

Gerard Espinosa1, Ricard Cervera, Josep Font

  • 1Department of Autoimmune Diseases, Institut Clínic d'Infeccions i Immunologia, Hospital Clínic, Villarroel 170, 08036 Barcelona, Catalonia, Spain.

Autoimmunity Reviews
|July 10, 2003
PubMed
Summary
This summary is machine-generated.

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Antiphospholipid antibodies (aPL) strongly associate with thrombosis. This review explores how aPL may cause blood clots by affecting cell membrane reactions or stimulating cells to alter molecule expression and secretion.

Area of Science:

  • Immunology
  • Hematology
  • Pathophysiology

Background:

  • Antiphospholipid antibodies (aPL) are linked to thrombosis.
  • The exact mechanisms by which aPL cause thrombotic events remain unclear.

Purpose of the Study:

  • To review the proposed pathophysiological mechanisms of thrombosis development in the presence of aPL.
  • To elucidate the role of aPL in thrombotic events.

Main Methods:

  • Literature review of proposed pathophysiological mechanisms.
  • Categorization of mechanisms into two main types.

Main Results:

  • aPL may disrupt the kinetics of procoagulant and anticoagulant reactions on cell membranes.
  • aPL may stimulate cells, altering the expression and secretion of various molecules.

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Conclusions:

  • Understanding these mechanisms is crucial for clarifying the pathogenic role of aPL in thrombosis.
  • Further research into these pathways can inform therapeutic strategies.