Related Experiment Video
Updated: Aug 9, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
Genes and parkinsonism
John Hardy1, Mark R Cookson, Andrew Singleton
1Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Abstract:
Genetic studies in families with mendelian inheritance of Parkinson's disease (PD) have reported the cloning of several disease-associated genes. These studies of rare familial forms of the disease have cast doubt on our understanding of the role of genetics in typical PD and have complicated the classification of the disorder. However, this genetic information might help us to construct a hypothesis for the pathogenetic processes that underlie PD. In this review we describe the molecular genetics of PD as currently understood to help explain the pathways that underlie neurodegeneration.
Related Concept Videos
Neural Regulation
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology

