Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What is HER2?

T Cooke1

  • 1University Department of Surgery, Royal Infirmary, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, UK.

European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society
|July 10, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence of increasing public participation in advance care planning: a comparison of polls in Alberta between 2007 and 2013.

BMJ supportive & palliative care·2016
Same author

Growth inhibition of gastric cancer cell lines by the tyrphostin RG13022 and its effects on intracellular signalling.

International journal of oncology·2011
Same author

Prolonged access to the venous system using the Hickman right atrial catheter.

Annals of the Royal College of Surgeons of England·2009
Same author

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.

British journal of cancer·2008
Same author

Orthotopic ileal neobladder reconstruction after renal transplant.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
Same author

Rising to the challenges of achieving day surgery targets.

Anaesthesia·2006
Same journal

Self-management support in oncology: A concept analysis.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same journal

Digital behavioural weight loss interventions for weight management in breast cancer survivors: A meta-analysis.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same journal

Unmet needs of patients with cancer undergoing radiotherapy in Korea: A qualitative study.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same journal

Cancer-related stigma in gynaecological cancers: A mixed-methods systematic review of quantitative associations and qualitative experiences.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same journal

Dyadic emotional and behavioral experiences in pediatric leukaemia: An interpretative phenomenological analysis of parent-child dynamics in Pakistan.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same journal

Factors associated with reproductive concerns among adolescent and young adult cancer survivors: A cross-sectional study.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
See all related articles

Mutations in growth factor receptors, like human epidermal growth factor receptor 2 (HER2), drive cancer. HER2 amplification in breast cancer correlates with poor prognosis, making HER2 status crucial for patient management.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer development is linked to mutations in cell growth-regulating systems, particularly growth factor receptors.
  • The human epidermal growth factor receptor (HER) family plays a key role in normal growth regulation and is well-studied in breast cancer.
  • HER2 is a central member of the HER family, crucial for potentiating intracellular signaling pathways.

Purpose of the Study:

  • To investigate the role of HER2 gene amplification and receptor overexpression in oncogenesis.
  • To highlight the significance of HER2 in breast cancer progression and patient prognosis.
  • To emphasize the clinical importance of determining HER2 status in breast cancer management.

Main Methods:

  • Review of existing research on growth factor receptors and oncogenesis.

Related Experiment Videos

  • Analysis of studies linking HER2 gene amplification/receptor overexpression to cancer development.
  • Examination of the association between HER2 status and patient outcomes in breast cancer.

    • Main Results:

    • Mutations affecting growth factor receptors are implicated in cancer initiation (oncogenesis).
    • HER2 gene amplification/receptor overexpression is observed in a substantial percentage of various tumor types.
    • HER2 amplification/overexpression occurs early in cancer progression and is linked to poorer prognosis in breast cancer patients.

    Conclusions:

    • HER2 gene amplification/receptor overexpression is a significant factor in the development and progression of various cancers, notably breast cancer.
    • Determining the HER2 status of breast cancer patients is essential for informed clinical decision-making and treatment planning.
    • Further research into HER2 function and regulation is warranted given its pivotal role in cancer.